Melanotan 2 Powder
specification: Melanotan 2 5MG, Melanotan 2 10MG
Peptide.ltd has more than 20 years of peptides R&D and production technology, we can provide 1000+ multiple peptides, from “mg” to “gram” which is suitable for a variety of research fields, bulk quantities available also. We provide professional customization services with fast delivery. Some products can provide DMF certificates.
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Sequence: | Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1) |
Molecular Formula: | C50H69N15O9 |
Molecular Weight: | 1024.198 g/mol |
PubChem CID: | 92432 |
CAS Number: | 121062-08-6 |
Synonyms: | Melanotan-II, MT II, MT2, Melanotan 2 |
1.What is Peptide Melanotan II (MT2)?
Melanotan II, also known as Melanotan 2, MT2, MT-2 and MT-II, is a synthetic peptide that mimics the structure and properties of melanocyte stimulating hormone (MSH). MSH is a peptide hormone that plays a role in the immune, cardiovascular and nervous systems and has potential benefits in skin pigmentation, energy balance, cellular inflammation and sexual function.
Melanotan II can help tan by stimulating melanocytes to increase melanin production, and can also increase sexual arousal and control hunger.
Similar to Melanolan II, another synthetic analog of α-melanocyte stimulating hormone is Melanotan I (Afamelanotide). Melanotan I has been approved by the FDA for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. Unlike Melanotan I, which is a 13-amino acid linear peptide, Melanotan 2 is a cyclic peptide containing only 7 amino acids. Therefore, their effects are also different.
2.How does Melanotan II (MT2) Work on our body?
Although Melanotan II is an analogue of MSH, Melanotan II is 1000 times more powerful than MSH and can act on melanocortin receptors to varying degrees and produce various effects. Melanotan-II (MT2) works by interacting with melanocortin receptors in the body. Here is a list of the receptors involved:
MC1R: Melanocytes, which produce pigment in the skin, hair follicles, and eyes, are the primary cells that express MC1R. The activation of MC1R by alpha-melanocyte-stimulating hormone (-MSH) promotes melanin production and distribution, resulting in skin and hair pigmentation.
MC2R: It is present mostly in the adrenal glands, specifically in the outer layer known as the adrenal cortex. It is essential for the generation and release of cortisol, a hormone implicated in stress reactions and a variety of metabolic activities.
MC3R: It is found throughout the central nervous system, including sites important in hunger regulation and energy balance, such as the hypothalamus. It is also prevalent in peripheral tissues such as the GI tract and adipose tissue.
MC4R: It is found mostly in the brain, notably in areas linked with hunger control, such as the hypothalamus. It is essential for controlling food intake and energy expenditure. Mutations in the MC4R gene have been linked to inherited forms of obesity.
MC5R: MC5R is found in a variety of tissues, including the skin, hair follicles, immune cells, and exocrine glands. Its precise roles are currently being researched.
It is worth noting that the MC1R is nearly entirely a pigment receptor that is present on cells where pigmentation is known to be significant, such as the eyes. To avoid the sunless tanning characteristics of melanocortins, it would be critical to avoid binding to this receptor. Though MT2 binds to MC1R with less affinity than MT1 or -MSH, it nevertheless binds and causes skin pigmentation.
The MC3R, like the MC4R, is broadly distributed in the central nervous system. These two receptors are expected to be of considerable importance in the future since they are most likely to govern the effects of melanocortin on things like behavior. One of the primary goals of melanotan 2 and other melanocortin research is to understand how these receptors work and how they may be precisely targeted.
3.What are the possible benefits of Melanotan II (MT2)?
Melanotan II has been formally investigated in clinical trials for tanning and erectile dysfunction benefits. However, research into melanocortins and MT-II is still ongoing, and there is a substantial and rising body of evidence pointing to a wide range of additional physiological activities that MT-II can beneficially affect. For your convenience, below are some probable MT-II benefits:
①Melanogenesis is a process that results in tanning.
②Phototoxicity protection, i.e. photoprotective in persons with Erythropoietic Protoporphyria
③Enhances libido
④Increases immunity by activating Treg cells and improving Th1/Th17 balance
⑤Reduces inflammation in chronic conditions such as ulcerative colitis, irritable bowel syndrome, and Crohn’s disease.
⑥Lowers appetite while improving lipid and glucose regulation
⑦Neuroprotective through reducing neuroinflammation after brain injury, brain ischemia, spinal cord damage, and increasing peripheral nerve regeneration ability in post-lesion healing.
⑧Potential usage in the misuse of alcohol and drugs, including opioids and cocaine (reward cascade supportive).
⑨Enhance cardiovascular benefits such as anti-inflammation, reperfusion, and blood pressure increase.
4.What is the Potential Risks of Injecting Melanotan II (MT2)?
MT-II may bring some risks when we inject Melanotan II(MT2), it has been considered minimal and are normally only felt for a short period of time after administration, with the frequency and severity of symptoms being proportional to dosage.
Following administration, the following short-term adverse effects may occur:
- Flushing of the face
- Appetite suppression, nausea, and vomiting
- Spontaneous erections (priapism) in males 1-5 hours after injection, associated with yawning and stretching complicated
There is some worry that melanotan II may raise the risk of:
- Melanoma is a potentially fatal type of skin cancer.
- Mole coloration changes, new moles, and atypical melanocytic naevi
- Melanonychia is a discoloration of one or more nails that ranges from brown to black.
- Rhabdomyolysis is the potentially deadly breakdown of muscle cells.
- Syndrome of Encephalopathy
Concerns have also been raised about potential side effects caused by contamination or a lack of sterility if melanotan II is prepared incorrectly or needles are shared. In summary, if MT-II is properly dosed, it is a safe and well-tolerated compound that causes only minor symptoms that typically resolve shortly after administration.
Melanotan 2 powder is the active ingredient of Melanotan 2 related products, it plays a very important role in the production of Melanotan 2 injection or oral etc related products. Peptide.ltd as a professional manufacturer of Melanotan 2 powder, provide Melanotan 2 raw powder in bulk, and offer custom peptide synthesis service.
It requires professional production technology to make various Melanotan II related finished products from raw Melanotan II powder.One of the most important criteria for measuring raw Melanotan II powder is purity(HPLC), but the test method also affects the test results. Professional labs or manufacturers of raw Melanotan II powder must have professional testing equipments and technology, and be able to provide information of professional testing methods, then the researchers who buying the raw Melanotan II powder can refer to and use. The documents usually include Certificate of Analysis, HPLC,MS…
Melanotan II powder for sale online to professional researchers and laboratories. There are sheer numbers of peptide manufacturers listing Melanotan II powder to buy and other research peptides for sale. It is advised that researchers or who are buying research Melanotan II is better to check their peptide vendors carefully before making a purchase. Are you looking for where to buy Melanotan II? You have come to the right place!
1.What Are The Advantages If Buy Melanotan 2 powder From Peptide.ltd?
①Competitive Factory Price: Factory direct sales, No middlemen make a difference.
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③Quality Guarantee: Professional lab reports along with shipment.
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⑤Easy Payment: Payment methods that are diverse.
⑥365/24/7 Service: High quality pre-sales and after-sales service, followed by product and order details consultation.
2.How To Buy Melanotan 2 Powder In Bulk From Peptide.ltd?
①Visit Melanotan 2 powder and send a quote request(include quantity,valid contact info. etc)
②A professional sales representative will contact you within 24 hours and provide you with effective information
③Order confirmed
④Parcel send out in time, package picture/tracking number etc provided
⑤Received parcel at your place
3.Does Peptide.ltd Provide Custom Synthesis Service?
YES, as a professional peptide manufacturer,we not only provide conventional specifications and products, but accept Custom Peptide Synthesis Order. Contact and get more details.
1.Is Melanotan II legal?
Melanotan II is a 7-amino acid synthetic peptide that, like many other research peptides, is only permitted for purchase, sale, and handling for research purposes. According to FDA restrictions, MT-II is not available as a medicinal product. As a result, MT-II cannot be sold for human consumption or for the treatment of any medical diseases in the United States, and similar restrictions apply in Europe.
Given the peptide treatments’ infancy, a minimum regulatory framework has been built, even within the legal peptide industry. This creates a difficult environment for the approval of peptide compounds for clinical trials and eventual distribution as medical goods.
Despite these obstacles, there is significant demand for peptide goods in the United States and many other nations across the world, with trends indicating increased future need.In response to the increased demand, the FDA has worked to develop rules for large-scale peptide manufacturing. These include stringent quality control standards for purity requirements, as well as a promise of improved transparency regarding peptide clinical pharmacology. The latter is designed to aid in the assessment of new peptide therapies in clinical trials.
Researchers are recommended to use caution and purchase materials from qualified vendors until these regulatory amendments are finalized. Most significantly, MT-II is totally legal as long as it is sourced from a qualified seller and handled by competent researchers.
2.How should Melanotan II often be taken?
Melanotan II (MT2) can be administered in the following ways:
Melanotan II injections: it is the most widely used and recommended mode of delivery. The MT2 solution is injected into the subcutaneous fat layer with a syringe, often in the belly, thigh, or buttock area. Before injecting, clean the injection site properly and use the right injection method as instructed by a healthcare expert.
MT2 Nasal Spray: Some providers provide MT2 as a nasal spray. You spray the MT2 solution into the nasal cavity with a spray bottle, allowing it to be absorbed through the nasal mucosa. This procedure is quite simple, but dose and absorption may differ.
3.How long do Melanotan 2 tanning injections last?
Melanotan II users should begin a maintenance phase of two injections per week after 2-3 weeks of daily treatment, or when the desired amount of pigmentation is obtained. When purchasing Melanotan 2 tanning injections, be in mind that the substance must be properly preserved. Unfortunately, if not stored properly, the components within it are quite unstable and will not be as effective when reconstituted.
4.Does Melanotan II help you gain muscle?
Although melanotan II has been shown to improve insulin sensitivity in mice, which could theoretically improve muscle building, MT-II is unlikely to have a significant impact on muscle building because it has been found to be an appetite suppressant, which is counterproductive for muscle gain. MT-II is unlikely to have a major impact on muscle growth, either positively or negatively.
5.Does Melanotan II Increase Testosterone?
During clinical trials, Melanotan II was found to have no effect on testosterone. MT-II is not expected to raise testosterone since it binds to melanocortin receptors, which do not alter testosterone production.
Melanotan 2 Peptide Dosage Calculator
Referenced Citations
[1] Wessells H, Levine N, Hadley ME, Dorr R, Hruby V. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9. doi: 10.1038/sj.ijir.3900582. PMID: 11035391.
[2] Hadley, M. E., & Dorr, R. T. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides, 27(4), 921–930.
[3] M. M. Sirufo, L. M. Magnanimi, L. Ginaldi, and M. De Martinis, “Anorexia nervosa and autoimmune comorbidities: A bidirectional route?,” CNS Neurosci. Ther., vol. 28, no. 12, pp. 1921–1929, Sep. 2022, doi: 10.1111/cns.13953.
[4] Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol. 2004 Jul;182(1):123-32. doi: 10.1677/joe.0.1820123. PMID: 15225137.
[5] Olney JJ, Sprow GM, Navarro M, Thiele TE. The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice. Neuropeptides. 2014;48(1):47-51. doi:10.1016/j.npep.2013.11.001.
[6] Hjuler, K. F., & Lorentzen, H. F. (2014). Melanoma associated with the use of melanotan-II. Dermatology (Basel, Switzerland), 228(1), 34–36.
[7] J. K. van den Heuvel et al., “Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets,” Front. Behav. Neurosci., vol. 9, p. 358, Dec. 2015, doi: 10.3389/fnbeh.2015.00358.
[8] Zhang Y, Collazo R, Gao Y, Li G, Scarpace PJ. Intermittent MTII application evokes repeated anorexia and robust fat and weight loss. Peptides. 2010;31(4):639-643. doi:10.1016/j.peptides.2009.12.019.
[9] Han D, Wang Y, Chen J, Zhang J, Yu P, Zhang R, Li S, Tao B, Wang Y, Qiu Y, Xu M, Gao E, Cao F. Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury. J Pineal Res. 2019 Aug;67(1):e12571. doi: 10.1111/jpi.12571. Epub 2019 Apr 12. PMID: 30903623.
[10] Wang W, Guo DY, Lin YJ, Tao YX. Melanocortin Regulation of Inflammation. Front Endocrinol (Lausanne). 2019;10:683. Published 2019 Oct 9. doi:10.3389/fendo.2019.00683.
[11] ANDAs for Certain Highly Purified Synthetic Peptide Drug Products That Refer to Listed Drugs of rDNA Origin (2021).
[12] Krashes, M. J., Lowell, B://. B., & Garfield, A. S. (2016). Melanocortin-4 receptor-regulated energy homeostasis. Nature neuroscience, 19(2), 206–219.
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine. The author of this article does not encourage any purchase of Melanotan II. If you have any purchase needs, please seek help from the customer service representative.
Scientific Journal paper Author:
- Mariël P Ter Laak
Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
- Joakim Riikonen
Department of Physics and Mathematics, University of Eastern Finland, Kuopio, Finland
- Ryouichi Banno
Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine
- Hiroshi Arima
Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiyskaya Street, 125315 Moscow, Russia
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.