CJC-1295
This product contains:CJC-1295 with DAC, CJC-1295 without DAC
Other names:CJC-1295, CJC-1295 no DAC, CJC-1295 without DAC,CJC-1295 (DAC), CJC 1295 with DAC, CJC-1295 DAC; CJC-1295+DAC, CIC- 1295 Acetate, Mod GRF (1-29), Modified GRF 1-29, DAC:GRF, GHRH derivative;Modified GRF (1-29) with Drug Affinity Complex, CJC-1295 Drug Affinity Complex, CJC-1295 with Drug Affinity Complex Peptide, (DAC) Peptide, GRF (1-29) with Drug Affinity Complex, CJC-1295 DAC Peptide
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) designed to elevate plasma levels of growth hormone and insulin-like growth factor 1 (IGF-1). CJC-1295 DAC is a specially designed peptide known as the best hGH secretagogue. DAC (Drug Affinity Complex) prolongs half-life partially by binding to serum albumin and protects CJC-1295 DAC peptide from degradation. The peptide is intended to treat visceral fat deposition in obese AIDS patients, as increased levels of exogenous HGH are thought to increase lipolysis (fat loss). In meanwhile, CJC-1295 has proven to help with fat loss and increase cellular repair and regeneration.
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Properties
Description
Manufacturers/Factory
Coa & Ms
Where to buy?
FAQ
Reviews
Properties
| Sequence: | Tyr-D-Ala-Asp-Ala-le-Phe- Th-GIn-Ser-Ty-Arg-Lys-Val-Leu-Ala-GIn-Leu-Se-Ala-Arg-Lys-Leu-Leu-GIn-Asp-lle-Leu-Ser-Arg |
| Molecular Formula: | C152H252N44O42 |
| Molecular Weight: | 3367.954 g/mol |
| PubChem CID: | 56841945 |
| CAS Number: | 863288-34-0 |
| Synonyms: | CJC-1295; CJC 1295 with DAC; CJC-1295 DAC; CJC-1295+DAC; CJC-1295 NO DAC; |
Description
CJC-1295 Peptide Structure
Authoritative source：PubChem
What is CJC–1295, DAC or no DAC?
CJC-1295, also known as DAC:GRF(DAC stands for drug affinity complex), which was originally developed by ConjuChem Biotechnologies, as a treatment for growth hormone deficiency. It’s a synthetic peptide that can stimulate growth hormone secretion (GH). Generally, peptides degrade over time whatever it as a natural peptide created in your body or a synthetic variation. However, DAC can prevent this to happen and keep same biological activity in the peptides. Nowadays, the market appear 2 form of CJC-1295 peptide sale online, CJC-1295 with DAC, CJC-1295 without DAC(also known as Modified GRF 1-29), they’re both synthetic peptides that are a modified version of endogenous GHRG (1-29).[10][5][12] However, since its inception, fitness enthusiasts and bodybuilders alike have found CJC-1295 particularly useful in gaining muscle, it works by increasing protein synthesis and insulin-like growth factor levels, can promote muscle tissue to grow, increase muscle mass and function.[13][10][1][2]
CJC 1295 with DAC is a growth hormone peptide, also it’s called CJC 1295 + DAC, which is synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids, ussually it’s a white crystalline powder and needs to be reconstituted.[12][14][11][9] With similar function to growth hormone releasing hormone.[10][4]This means that your body can increase lean muscle, improve bone density and higher IGF-1 levels, when taking CJC-1295 with DAC. Recent research studies have shown that CJC – 1295 + DAC stimulates GH and IGF-1 Secretion, and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss and increases protein synthesis.[2][7] So, CJC 1295 with DAC is known for being the finest of the hGH secretogues.[11][6][2]
CJC 1295 without DAC(also called Modified GRF 1-29, CJC 1295 no DAC), is a synthetic peptide that stimulates growth hormone production, which be further modified from its GRF 1-29 variation, can stimulates growth hormone production.[9][8] It is able to assist with rapid body fat reduction and faster recovery from strenuous activity, to promote substantial muscle gain and lean body composition, then help you improve your gains as well as overall health.[8]
When you plan to buy finished peptide of CJC 1295 with/no DAC online, usually it comes as a 2mg/vial, 5mg/vial, 10vial/vial in lyophilized form appeared, better to choose top quality peptide manufacturer or seller with trusted comments, can ensure quality issue, help you to get an amazing effect and achieve your goal.[14][13][6]
CJC-1295 with or without DAC, How to work?
CJC-1295 without/+ DAC is a peptide supplement that can stimulate the anterior pituitary to release more growth hormone, both peptide works by stimulating growth hormone secretion by binding to GHRH receptors and should stimulate the secretion of the whole family of growth hormone peptides normally secreted by the pituitary gland. These hormones will stimulate increases in bone density and collagen production, as well as boosting the immune system, leading to stimulate the production of lean muscle mass.[3][4]
CJC-1295 with DAC can be combined with growth hormone releasing peptides for enhanced peptide cycling results.[3][4][10][7] CJC-1295 DAC is commonly paired with growth hormone replacement peptide (GHRP) 6 or GHRP-2.[14][15][12] Combined use of CJC-1295 DAC with GHRP’s will accelerate fat loss and weight loss and stimulate anabolic effects via growth hormone induced fat breakdown. Overall, CJC-1295 with DAC will stimulate protein synthesis and fuel the growth of lean muscle tissue. The peptide also promotes faster injury recovery, a reduction in body fat and increased muscle mass. The growth stimulatory properties of CJC-1295 DAC will also stimulate cell growth and division to improve skin health, healing and immune system function.[15]
CJC 1295 without DAC is a peptide hormone made of amino acid, can increases lean muscle mass, boost muscle strength and losesbody fat, the only difference to other growth hormones on the market, CJC-1295 no DAC have an extended lifespan, can last longer in your body to increase the growth hormones dispersal rate.[11][2][8][3]
CJC-1295 with or without DAC, what‘s the benefit?
CJC-1295 with or without DAC have the same benefits, following include but are not limited to:
Increasing Bone Density: CJC-1295 w/no DAC can increase bone density, to reduce the risk of fractures and promote overall bone health.[13][14]
Increasing Muscle Mass: CJC-1295 w/no DAC can promote muscle growth by enhancing protein synthesis and increasing the number of muscle cells, leading to increase muscle mass, improve muscle tone and increase strength.[7][11][12][6]
Increasing Fat Burning Ability: CJC-1295 w/no DAC can increase muscle mass, to improve body’s resting metabolic rate, resulting more calories burned throughout the day.
Increasing Sex Drive: CJC-1295 w/no DAC can improve HGH levels, enhances libido, performance, and overall satisfaction.[15][12]
Strengthening the cardiovascular system: more muscle mass = higher metabolism = less body fat.[10][14][3]
Enhancing Immune System : CJC-1295 w/no DAC can achieve a strong immune system, to achieve optimal health.
Improving Insulin Sensitivity: CJC-1295 w/no DAC can improve insulin sensitivity, which can lead to better blood sugar control, reduced fat storage and improved overall metabolic health.
Improving Cognitive and Memory Function:CJC-1295 w/no DAC has overall benefits for the body, including focusing throughout the day and feeling mentally clear and sharp.[10][13]
How To Use CJC-1295 with or without DAC?
CJC-1295 + DAC and CJC-1295 without DAC (also known as Modified GRF 1-29) are both Growth Hormone Releasing Hormones (GHRH), they work same function in the human body. Both via subcutaneous injection (above the muscle, below the skin) in the stomach or abdominal regio.[11][7] CJC-1295 without DAC usually be taken once daily, it also have a recommend plan“5 days a week”, either with skipping days every 2 or 3 days, or weekdays on, weekends off for injections. But in both cases, the effects of CJC-1295 – higher circulating levels of human growth hormone – tend to last for upwards of a week following administration and continue at that level so long as the administration continues a few times a week.[5][6]
What are the side effects of CJC-1295 with or without DAC?
Generally, the use of CJC 1295 with or without DAC is safe under correct dosage and properly administered, and if any side effects, that are usually mild.
The most common side effects include:
Sensitivity at the injection site
mild soreness or pain
Headache
Dizziness
nausea
fatigue
drowsiness
flushing, hives, or other skin reactions
Hyperactivity
hard to swallow
However, if any symptoms persist then you may want to consult your doctor.
CJC-1295 with DAC vs CJC-1295 without DAC, What’s the Difference?
Half-life For CJC-1295 vs CJC-1295 DAC
CJC-1295 without DAC is closer to the body’s own peptide, it can use to work same way in the body.[11][1][13] Like GHRH, the half-life of CJC-1295 without DAC is very short, about 30 minutes.[9][14][3]
While, CJC-1295 + DAC has a half-life that can last up to approximately 6~8 days. It allows the peptide to better bind to the protein albumin in the blood, leading to have an effect for a long time.[13][8][10]
Dosage For CJC-1295 vs CJC-1295 DAC
Another big change between CJC 1295 with and without DAC is the dose difference.[4] When it has the DAC added in, you’re looking at between 1000mcg and 2000mcg per dose. However, when looking at CJC 1295 without DAC, these doses are much smaller at 100mcg per dose and can be taken up to three times in a day, making your daily dose 300mcg.
Effect For CJC-1295 vs CJC-1295 DAC
CJC-1295 with and without DAC almost have same effect. However, CJC-1295 DAC is sometimes used for burns or for significant soft-tissue, it helps the body repair these types of tissues after some surgeries.[13][14][11][5] It may be one additional application of CJC-1295 DAC beyond the uses that the two have in common (which are building muscle, burning fat, anti-aging effects, and better sleep).[1][9][8][5][7][9]
CJC-1295 DAC & Ipamorelin
CJC-1295 DAC and ipamorelin are often combined therapy because they are known to work well together. CJC-1295 takes 1-4 hours to reach peak serum levels in the blood, whereas ipamorelin acts much faster.[5] Ipamorelin has a half-life of about 2 hours, so it is cleared from the body more quickly. The combination of the two peptides ensures the rapid onset of action of ipamorelin and the long-lasting effect of CJC-1295 DAC.[9][11] These two peptides are incredibly specific in increasing growth hormone levels compared to other peptides. Other peptides can increase cortisol levels (as seen with stress, which can increase hunger), but neither ipamorelin nor CJC-1295 had an effect on the other hormones, which is a big plus.[11]
CJC-1295 For Sale |CJC-1295 Suppliers
The effects of CJC-1295 with or without DAC have been researched thoroughly. It is beneficial in building muscle, losing body fat, and boosting energy levels. It does all these by facilitating the production of more growth hormone for your body.
CJC-1295 with or without DAC is a releasing factor for growth hormone.[4] This substance has potential performance-enhancing effects, it is readily available, and there is reason to believe that it is being used within the bodybuilding community.[11][12]
Make sure buyers interested in CJC-1295 with or without DAC source this peptide from a reliable supplier.[15][2] When you are buying CJC-1295 with or without DAC online, please exercise caution and make sure you are getting the peptide from a reputable and trustworthy manufacturer.[7] peptide.ltd is a highly reliable manufacturer supplying you Pharmaceutical Grade Peptides.
Manufacturers/Factory
CJC 1295 is a very new peptide on the market, that is legally selling as a research chemical in the United States, Canada, and the UK as well as the majority of nations on earth, typically sold as lyophilized (freeze-dried) powder in amounts of 2mg/5mg/10mg per vial, without fear of legal repercussion.
Nowadays, many bodybuilder alike to buy CJC-1295 with or without DAC for sale online, to promote lean muscle growth, reduces fat, aids recovery. Or, using the therapy with Peptide CJC-1295 with DAC & CJC-1295 without DAC.[14][1][2] Suggest each users should make an informed decision before buying Peptide CJC-1295 with DAC & CJC-1295 without DAC to avoid the risk of potential side effects, health and safety are always prioritize for all people, keep informed about the latest research developments on peptide CJC1295.
The best CJC-1295 with DAC & CJC-1295 without DAC peptide manufacturer, peptide.ltd is not only supply the peptide CJC-1295 in powder form but provide the customized standard easy use vial form, which follows strict packaging and manufacturing protocols to ensure the purest and most stable form of peptide.
You can buy the best price of CJC-1295 with DAC & CJC-1295 without DAC at semi-finished vials and best quality peptide from this professional peptide manufacturer
Coa & Ms
Where to buy?
Polypeptide Co., Ltd. is the most reliable CJC-1295 with DAC & CJC-1295 without DAC manufacturer in China.[10][9][3][8] Our factory is committed to producing high-quality CJC-1295 with DAC & CJC-1295 without DAC 5mg per vial. We welcome all demanders and buyers of pure CJC-1295 powder to contact us!
In order to ensure the quality of the peptide should avoid buying bulk CJC-1295 with DAC & CJC-1295 without DAC. The advantages of Peptide Co.[6][9][14][15] Wholesale CJC-1295 with DAC & CJC-1295 without DAC include:
①Scale production, stable supply, short delivery cycle and high price competitiveness;
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⑤Excellent pre-sales and after-sales service
What Are The Advantages If Buy CJC-1295 with DAC & CJC-1295 without DAC From peptide.ltd?
- Competitive Factory Price-Factory direct sales, No middlemen make a difference.[13][7][6]
- Customization Service-Product specifications can be customized to create your own peptide brand.[13]
- Quality Guarantee-Professional lab reports along with shipment.
- Fast Shipping-Professional logistics customization solutions, on-time delivery.[1][13][2]
- Easy Payment-Payment methods that are diverse.
- 365/24/7 Service-High quality pre-sales and after-sales service, followed by product and order details consultation.[1]
How To Get The Quick Price Of CJC-1295 with DAC & CJC-1295 without DAC Online?
- 1)Visit professional CJC-1295 with DAC & CJC-1295 without DAC supplier Polypeptide.[1]ltd, choose the CJC-1295 with DAC & CJC-1295 without DAC you want to buy.
- 2) Leave your contact and message on peptide.ltd website, then submit to peptide.ltd.[14][2][15]
- 3) The customer service will reply you in 12 hours once received your message, then talk in details about buy CJC-1295 with DAC & CJC-1295 without DAC.
Does peptide.ltd Support The Free Sample Of CJC-1295 DAC Powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.
Can I Appoint The CJC-1295 with DAC & CJC-1295 without DAC Color When Buy CJC-1295 with DAC & CJC-1295 without DAC?
YES! peptide.ltd as peptide manufacturer, provide colour customization of CJC-1295 with DAC & CJC-1295 without DAC, easy to help you to build your CJC-1295 with DAC & CJC-1295 without DAC peptide brand.[13][15][9][11]
Can I Appoint The Products Standard When Buy CJC-1295 with DAC & CJC-1295 without DAC From peptide.ltd?
YES! As one of the best CJC-1295 with DAC & CJC-1295 without DAC manufacturer, peptide.ltd not only provide the standard specification of CJC-1295 with DAC & CJC-1295 without DAC in 5mg, 10mg, but support standard customization. Provide the best support to build your own CJC-1295 with DAC & CJC-1295 without DAC brand.
Can I Buy CJC-1295 DAC In Pure Powder Form From peptide.ltd?
YES! CJC-1295 DAC powder is the base that use for CJC-1295 with DAC & CJC-1295 without DAC lyophilized powder manufacture.[6] peptide.ltd provide CJC-1295 with DAC & CJC-1295 without DAC in both of pure powder form and semi-finished vial form.
Can I Buy Discount CJC-1295 Powder From peptide.ltd?
YES! Our factory produce high quality CJC-129 powder in term and keep CJC-1295 powder in stock. You can buy high quality CJC-1295 with DAC & CJC-1295 without DAC powder in bulk.[3][5] During promotion sale, you can buy CJC-1295 with DAC & CJC-1295 without DAC peptide by lower price.[13][10] You can keep touch with our customer manager and they will update the latest bulk CJC-1295 with DAC & CJC-1295 without DAC price for you in time.[13][7]
FAQ
What is DAC peptide？
The Drug Affinity Complex(DAC) is developed by ConjuChem addreddes.[14] It main production is protecting peptides from peptidase degradation as well as preventing rapid kidney excretion in order to prolonging the half life of peptides. Polypeptide CJC 1295 DAC is a kind of DAC peptide.
What is CJC-1295 and what is CJC-1295 DAC?
CJC 1295 is a analogue of GHRH (growth hormone releasing hormone).[15][2][12] It is known for its ability to upregulate growth hormone (GH) levels in blood.[1][8][4]
CJC-1295 was further modified by adding a DAC(Drug Affinity Complex) to extend its half-life.[8][11] This is called CJC1295 DAC.
Where to buy CJC DAC or CJC1295 no DAC?
CJC-1295 DAC is a releasing factor for growth hormone.[11][3][2] People who are interested in it can find a good CJC1295 supplier online to buy it. Polypeptide has CJC 1295 with DAC and CJC1295 no DAC for sale now.[14][4]
CJC 1295 VS CJC 1295 DAC, which is better?
There is no doubt that CJC 1295 with DAC is better than CJC-1295 without DAC.[15][3] Because CJC DAC 1295 has a longer half-life, and it remains in the blood for a longer period of time.[3][4][7]
What is CJC 1295 without DAC ‘s dosage?
CJC 1295 without DAC is for research purpose only.[15][6] It is also called GRF(1-29). And because CJC-1295 no DAC is a modidied version of Sermorelin, it has the similar dosage as Sermorelin.[9][6]
That is, for an 80-pound researcher, the daily dose would be 0.8 mg.[15][10][14][8]
What is CJC 1295 dosage for muscle building?
Because CJC-1295 with DAC has not to undergo human clinical trials, dosage studies on it are limited.[13][6] In the published dose studies on CJC1295 with DAC, it can be concluded that regardless of the researcher’s weight, the dose of CJC-1295 DAC should be at 2mg per week.[14][12][5]
What is the difference between CJC-1295 and CJC-1295 DAC?
The biggest difference between CJC DAC and CJC no DAC is that CJC with DAC has added an extra corpuscle to CJC without DAC called “Drug Affinity Complex”.[15] And extend CJC 1295 half life from about 30 minutes to about 6 to 8 days.[14][10][5]
What is CJC 1295 with DAC 5mg?
CJC-1295 with DAC 5mg is in the form of lyophilized powder. It is administered via injection, and it requires bacteriostatic or sterile water for reconstitution. Polypeptide CJC-1295 DAC 5mg is a peptide that stimulates the pituitary gland to release more Human Growth Hormone(HGH).[2][9]
What are CJC-1295 with DAC benefits ?
The main function of CJC-1295 with DAC is to elevate plasma levels of growth hormone and insulin-like growth factor 1 (IGF-1). And it will brings there benefits:
- Helping with Muscle Growth
- Helping to increasing Body weight
- Increasing Fat Loss
- Help with Injury Recovery
- Improving Immune Function
What are CJC 1295 with DAC side effects
People who want to buy CJC1295 DAC or no DAC for research may curious about the side effects of CJC1295.
Like all drugs, CJC1295 can have some side effects, but these are few and occur rarely.[3][11][12] Most people who research CJC1295 have found few or no effects for a short period of time.[2][13]
Despite this, it is still important to aware these, The current potential side effects of CJC-1295 are as follows:
Diarrhea;
Headache;
Nausea;
Increased heart rate;
Flushing;
Side effects may be dose-related.[6][1] Therefore, if these similar symptoms occur during the research, please reduce the dose immediately or stop continuing the research.
What is the best combination with CJC-1295?
The combination of CJC-1295 and Ipamorelin peptides is recommended for the best peptide treatment, as they can act together to increase levels of growth hormone in the blood.[13][11]
Reviews
CJC-1295 with DAC, CJC-1295 without DAC Peptide Dosage Calculator
Referenced Citations
[1]Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. Epub 2005 Dec 13.
[2]Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009 Dec;19(6):471-7. doi: 10.1016/j.ghir.2009.03.001. Epub 2009 Apr 21.
[3]Jump up to:a b c d e f Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (March 2006). “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults”. The Journal of Clinical Endocrinology and Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. PMID 16352683.
[4]Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, et al. (July 2005). “Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog”. Endocrinology. 146 (7): 3052–8. doi:10.1210/en.2004-1286. PMID 15817669.
[5]Jump up to:a b c Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R (December 2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology. Endocrinology and Metabolism. 291 (6): E1290-4. doi:10.1152/ajpendo.00201.2006. PMID 16822960.
[6]Ionescu M, Frohman LA (December 2006). “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog”. The Journal of Clinical Endocrinology and Metabolism. 91 (12): 4792–7. doi:10.1210/jc.2006-1702. PMID 17018654.
[7]“Current Research Findings Regarding CJC-1295”. Neo Scientific. 2 June 2015. Archived from the original on 7 April 2019. Retrieved 3 August 2015. The reason why CJC1295 possesses the ability to lengthen the half-life within the active agent has to do with the scientific process known as bioconjugation. This technology, which is relatively new in nature, is defined by its ability to take a reactive group and bond it to a peptide (Aslam and Dent). This attachment causes a reaction with a nucleophilic unit; a typically partially molecule that is found within the bloodstream of an animal test subject. This reaction in turn causes a more stable bond to occur. This specific peptide has an especially high attraction to albumin, a globular protein that is soluble in water. This affinity prohibits natural degradation, which in turn increases the peptide’s half-life (Hermanson). Additionally, clinical research performed on animal test subjects has thus far shown that there have been no signs of DPP-IV degradation present when CJC-1295 was introduced (Gonzalez, US Peptide Articles).
[8]Henninge J, Pepaj M, Hullstein I, Hemmersbach P (2010). “Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation”. Drug Testing and Analysis. 2 (11–12): 647–50. doi:10.1002/dta.233. PMID 21204297
[9]Alba, M, Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori,R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
[10]Van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC- 1295: pulses and potions. Substance Use & Misuse, 51(), 73-84.
[11]National Center for Biotechnology Information. “PubChem Compound Summary for CID 91976842, CJC1295 Without DAC” PubChem.
[12]Timms M, Ganio K, Steel R.”A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS”Drug Test Anal. 2019 Aug;11(8):1248-1257. doi: 10.1002/dta.2599. Epub 2019 May 8.PMID: 30938069.
[13]Kwok WH, Ho EN, Lau MY, Leung GN, Wong AS, Wan TS.” Doping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry”Anal Bioanal Chem. 2013 Mar;405(8):2595-606. doi: 10.1007/s00216-012-6697-9. Epub 2013 Jan 15.PMID: 23318763.
[14]Memdouh S, Gavrilović I, Ng K, Cowan D, Abbate V.”Advances in the detection of growth hormone releasing hormone synthetic analogs” Drug Test Anal. 2021 Nov;13(11-12):1871-1887. doi: 10.1002/dta.3183. Epub 2021 Nov 7.PMID: 34665524.
[15]Pineau T, Schopfer A, Grossrieder L”The study of doping market: How to produce intelligence from Internet forums”Forensic Sci Int. 2016 Nov;268:103-115. doi: 10.1016/j.forsciint.2016.09.017. Epub 2016 Sep 27. PMID: 27710891.
CJC-1295 Overview
Growth hormone-releasing hormone (GHRH) has undergone several modifications to create analogs that retain certain effects while eliminating others. Among these modifications is CJC-1295, which encompasses the first 29 amino acids of GHRH. CJC-1295, technically a maleimido derivative of hGRF(1-29), was developed to enhance solubility as a growth hormone secretagogue and facilitate large-scale production while maintaining the physiological actions of GHRH.[1][2][3]
CJC-1295 Versus CJC-1295 DAC
CJC-1295 is a derivative of the initial 29 amino acids of growth hormone-releasing hormone (GHRH), making it structurally akin to other GHRH analogs such as Sermorelin. Although it bears the greatest resemblance to modified GRF (1-29), the two peptides are not identical. Much confusion arises due to the peptide’s similarities with others and the inclusion of a supplementary chemical compound known as the drug affinity complex (DAC) in the original formulation of CJC-1295.
Half-life of CJC-1295-DAC compared to standard growth hormone releasing factor (GRF)
Authoritative source：Oxford Academic
Initially, ConjuChem Biotechnologies, the creator of DAC, labeled the peptide with DAC as CJC-1295. However, this caused confusion as the peptide was also available without DAC. To alleviate this confusion, the version of CJC-1295 that includes DAC is now referred to as CJC-1295-DAC, while the version without DAC is simply called CJC-1295 or CJC-1295-no DAC.
CJC-1295 Structure
Authoritative source：Oxford Academic
Sequence: Tyr-D-Ala-Asp-Ala-le-Phe- Th-GIn-Ser-Ty-Arg-Lys-Val-Leu-Ala-GIn-Leu-Se-Ala-Arg-Lys-Leu-Leu-GIn-Asp-lle-Leu-Ser-Arg
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.954 g/mol
PubChem CID: 56841945
CJC-1295-DAC Structure
Authoritative source：Oxford Academic
Sequence: Ty-D-Ala-Asp-Aa-l-Phe Th-GIn-Ser-TyT-Arg-Lys-Val-Leu-Ala-GIn-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gin-Asp-lle-Leu-Ser-Arg-Lys-DAC
Molecular Formula: C152H252N44O42
Molecular Weight: 3647.954 g/mol
PubChem CID: 91976842
CJC-1295 Research
CJC-1295 and Growth Hormone Release
Being a derivative of GHRH, it is expected that CJC-1295 stimulates the secretion of GH. Research indicates that a single dose of CJC-1295 can increase GH levels in mice by 2-10 times.[5][6][7] The highest GH levels are typically observed around 2 hours after administration, and the effects can last for approximately six days. Unlike other GH secretagogues, CJC-1295 maintains the natural physiological pattern of GH release. This means that the regular circadian peaks and troughs in GH secretion are preserved, making CJC-1295 a physiologically relevant growth hormone-releasing factor.
Preserving physiologic release of GH even while influencing the maximum concentration of the hormone in the bloodstream is critical to ensuring enhanced effects without increased side effects. In particular, CJC-1295 has been demonstrated to preserve growth hormone’s physiologic effects on hyperplasia, hypertrophy, bone density, blood sugar, fat metabolism, protein synthesis, and myocardial (heart cell) function.
CJC-1295 and Growth
Studies conducted on mice lacking normal GHRH physiology have demonstrated that CJC-1295 maintains the regular release of GH. This characteristic of the peptide holds potential for therapeutic applications in addressing abnormal growth in various mammalian species, including humans. Preserving the natural pulsatile release of GH is crucial in ensuring the appropriate secretion of downstream hormones, such as insulin-like growth factor-2 (IGF-1).
CJC-1295 and Infertility
Research conducted in the early 1990s suggests that CJC-1295 and other GRF analogues could potentially be beneficial in promoting ovulation in infertile female patients. It has been well-established that ovulation is dependent on IGF-1 and likely influenced by GH release and cycling. Animal studies focusing on superovulation have further supported these theories by demonstrating significant increases in both GH and IGF-1 levels during the ovulation period. Moreover, these studies indicate that the administration of exogenous GH secretagogues, such as CJC-1295, is sufficient to induce proper ovulation.[5][6] There is also speculation that CJC-1295 and similar analogues might have potential applications in male infertility by aiding in the regulation of sperm production, although this hypothesis has yet to be tested.
CJC-1295 Summary
CJC-1295 is a growth hormone secretagogue specifically designed to have a prolonged plasma half-life and to preserve the natural patterns of the GH axis. It has proven successful in achieving these goals. While the molecule initially generated limited interest in research settings due to the emergence of similar compounds and its proprietary nature, the ability to manufacture CJC-1295 more freely is likely to reignite curiosity in its properties, especially regarding its potential applications in addressing the challenging issue of human infertility.
In studies conducted on mice, CJC-1295 has demonstrated moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability. However, it is important to note that the dosage per kilogram used in mice is not directly applicable to humans. Consequently, the sale of CJC-1295 by Peptide Sciences is strictly limited to educational and scientific research purposes and is not intended for human consumption. Therefore, purchasing CJC-1295 is only appropriate for licensed researchers. [6][7]
Referenced Citations
[3] Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions [Tandfonline.com]
[4] M. Ionescu and L. A. Frohman, “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog,” J. Clin. Endocrinol. Metab., vol. 91, no. 12, pp. 4792–4797, Dec. 2006. [PubMed]
[5] M. Alba et al., “Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse,” Am. J. Physiol. Endocrinol. Metab., vol. 291, no. 6, pp. E1290-1294, Dec. 2006. [PubMed]
[6] A. Volpe, G. Coukos, A. Barreca, G. Giordano, P. G. Artini, and A. R. Genazzani, “Clinical use of growth hormone-releasing factor for induction of superovulation,” Hum. Reprod., vol. 6, no. 9, pp. 1228–1232, Oct. 1991. [PubMed]
[7] Jetté, Lucie & Leger, Roger & Thibaudeau, Karen & Benquet, Corinne & Robitaille, Martin & Pellerin, Isabelle & Paradis, Véronique & Wyk, Pieter & Pham, Khan & Bridon, Dominique. (2005). hGRF1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long Lasting GRF Analog. [Research Gate]
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.
scientific journal paper author:
Pharmacologie/toxicologie, laboratoire MassSpecLab, université Versailles-Saint-Quentin-en-Yvelines, Inserm U-1173, CHU Garches, 71180 Montigny-le-Bretonneux, France.
Department of Biological Sciences, Ohio University, Athens, Ohio 45701, United States.
Department of Neuroendocrinology, Medical Center of Postgraduate Education, Warsaw, Poland.
Department of Physiology, Faculty of Medicine, University of Córdoba, 14004 Córdoba, Spain.
Department of Clinical Physiology, Section of Clinical Neurophysiology, Karolinska Institute, Huddinge, Sweden
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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