Best MOTS-C 5mg and 10mg Peptides GMP Factory

MOTS-C

MOTS-C

Other names:UNII-A5CV6JFB78, A5CV6JFB78, MOTS-c (human) (trifluoroacetate salt)

Polypeptide MOTS-c, short for Mitochondrial-derived Short Open Reading Frame-c, is a recently discovered bioactive peptide with promising implications for metabolic health. The peptide was first identified in 2015 by a team of researchers studying the effects of exercise on mitochondrial function. It originates from a unique portion of the mitochondrial genome, known as the 12S rRNA, and is conserved across species, suggesting its evolutionary significance.

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Referenced Citations

[1]Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim  SJ.”MOTS-c reduces myostatin and muscle atrophy signaling.”Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8.PMID: 33554779

[2]Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z.”MOTS-c Functionally Prevents Metabolic Disorders.”Metabolites. 2023 Jan 13;13(1):125. doi: 10.3390/metabo13010125.PMID: 36677050

[3]Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC.”MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.”Int J Mol Sci. 2022 Oct 9;23(19):11991. doi: 10.3390/ijms231911991.PMID: 36233287

[4]Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P.”The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.”Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009.PMID: 25738459

[5]Zheng Y, Wei Z, Wang T.”MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.”Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. eCollection 2023.PMID: 36761202

[6]Kong BS, Min SH, Lee C, Cho YM.”Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes.”Cell Rep. 2021 Jul 27;36(4):109447. doi: 10.1016/j.celrep.2021.109447.PMID: 34320351

[7]Benayoun BA, Lee C.”MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.”Bioessays. 2019 Sep;41(9):e1900046. doi: 10.1002/bies.201900046. Epub 2019 Aug 5.PMID: 31378979

[8]Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X.”The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.”Pharmacol Res. 2022 Jan;175:105987. doi: 10.1016/j.phrs.2021.105987. Epub 2021 Nov 17.PMID: 34798268

[9]Zhang Z, Chen D, Du K, Huang Y, Li X, Li Q, Lv X.”MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria.”Mitochondrion. 2023 Jul;71:76-82. doi: 10.1016/j.mito.2023.06.002. Epub 2023 Jun 10.PMID: 37307934

[10]Yang B, Yu Q, Chang B, Guo Q, Xu S, Yi X, Cao S.”MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway.”Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166126. doi: 10.1016/j.bbadis.2021.166126. Epub 2021 Mar 13.PMID: 33722744

[11]Yi X, Hu G, Yang Y, Li J, Jin J, Chang B.”Role of MOTS-c in the regulation of bone metabolism.”Front Physiol. 2023 May 2;14:1149120. doi: 10.3389/fphys.2023.1149120. eCollection 2023.PMID: 37200834

[12]Kim KH, Son JM, Benayoun BA, Lee C.”The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.”Cell Metab. 2018 Sep 4;28(3):516-524.e7. doi: 10.1016/j.cmet.2018.06.008. Epub 2018 Jul 5.PMID: 29983246

[13]Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C.”MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.”Nat Commun. 2021 Jan 20;12(1):470. doi: 10.1038/s41467-020-20790-0.PMID: 33473109

[14]Kong BS, Lee C, Cho YM.”Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.”Diabetes Metab J. 2023 May;47(3):315-324. doi: 10.4093/dmj.2022.0333. Epub 2023 Feb 24.PMID: 36824008

[15]García-Benlloch S, Revert-Ros F, Blesa JR, Alis R.”MOTS-c promotes muscle differentiation in vitro.”Peptides. 2022 Sep;155:170840. doi: 10.1016/j.peptides.2022.170840. Epub 2022 Jul 14.PMID: 35842023

[16]Lee C, Kim KH, Cohen P.”MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.”Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016 May 20.PMID: 27216708

Author of this article:

Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Sandra García-Benlloch

Facultad de Medicina y Odontología, Universidad Católica de Valencia San Vicente Mártir, c/Quevedo 2, 46001 Valencia, Spain

Byung Soo Kong

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

Peng Lu

Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China

Zewei Zhang

School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, Fujian 350004, China

Yadong Yin

Department of Obstetrics and Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.

Author of this article:

Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.