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DSIP

DSIP

Other names:Delta Sleep-inducing peptide, Emideltide, DSIP nonapeptide, Deltaran, Delta Sleep-Inducing Substance, Delta Sleep-inducing peptide, Sleep-Inducing Factor

Delta-sleep-inducing peptide (DSIP) is a neuropeptide that exerts influence onvarious endocrine and physiological processes within the central nervous system. DSIP is particularly notable for its capacity to alleviate oxidative stress andrestore myocardial contractility. Additionally, it is under investigation as a potential therapeutic target for the treatment of major depressive disorder.

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Referenced Citations

[1]Bjartell A, Ekman R, Sundler F, Widerlöv E (1988). “Delta sleep-inducing peptide (DSIP): An overview of central actions and possible relationship to psychiatric illnesses”. Nordic Journal of Psychiatry. 42 (2): 111–117. doi:10.3109/08039488809103215. 

[2]Charnay Y, Bouras C, Vallet PG, Golaz J, Guntern R, Constantinidis J (1989). “Immunohistochemical distribution of delta sleep inducing peptide in the rabbit brain and hypophysis”. Neuroendocrinology. 49 (2): 169–175. doi:10.1159/000125110. PMID 2657475.

[3] Graf MV, Hunter CA, Kastin AJ (1984). “Presence of Delta-Sleep-Inducing Peptide-Like Material in Human Milk”. Journal of Clinical Endocrinology & Metabolism. 59 (1): 127–32. doi:10.1210/jcem-59-1-127. PMID 6547144.

[4]Gimble JM, Ptitsyn AA, Goh BC, Hebert T, Yu G, Wu X, Zvonic S, Shi XM, Floyd ZE (2009). “Delta sleep-inducing peptide and glucocorticoidinduced leucine zipper: potential links between circadian mechanisms and obesity?”. Obesity Reviews. 10: 46–51. doi:10.1111/j.1467-789X.2009.00661.x. PMID 19849801. S2CID 5943377.

[5]Iyer KS, McCann SM (November 1987). “Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat”. Brain Research Bulletin. 19 (5): 535–538. doi:10.1016/0361-9230(87)90069-4. PMID 3121137. S2CID 7710977.

[6]Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II (2003). “Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia”. Peptides. 24 (2): 307–311. doi:10.1016/S0196-9781(03)00040-8. PMID 12668217. S2CID 23492463.

[7]Koval’zon VM (1994). “[DSIP: the sleep peptide or an unknown hypothalamic hormone?]”. Zhurnal Evoliutsionnoi Biokhimii I Fiziologii (in Russian). 30 (2): 310–319. PMID 7817664.: Koval’zon VM (1994). “[DSIP: the sleep peptide or an unknown hypothalamic hormone?]”. Zhurnal Evoliutsionnoi Biokhimii I Fiziologii (in Russian). 30 (2): 310–319. PMID 7817664.

[8]Monnier M, Dudler L, Gächter R, Maier PF, Tobler HJ, Schoenenberger GA (April 1977). “The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide”. Experientia. 33 (4): 548–52. doi:10.1007/BF01922266. PMID 862769. S2CID 33287951.

[9]Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI (2003). “Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice”. Mechanisms of Ageing and Development. 124 (6): 721–731. doi:10.1016/S0047-6374(03)00082-4. PMID 12782416. S2CID 12666819.

[10]Pollard BJ, Pomfrett CJ (2001). “Delta sleep-inducing peptide”. Eur. J. Anaesthesiol. 18 (7): 419–422. doi:10.1046/j.1365-2346.2001.00917.x. PMID 11437870.

[11]Sudakova KV, Coghlan JP, Kotov AV, Salieva RM, Polyntsev YV, Koplik EV (1995). “Delta-sleep inducing peptide sequels in mechanisms of resistance to emotional stress”. Annals of the New York Academy of Sciences. 771 (1): 240–251. Bibcode:1995NYASA.771..240S. doi:10.1111/j.1749-6632.1995.tb44685.x. PMID 8597403. S2CID 40317428.

[12]Schoenenberger GA, Maier PF, Tobler HJ, Monnier M (1977). “A naturally occurring delta-EEG enhancing nonapeptide in rabbits”. European Journal of Physiology. 369 (2): 99–109. doi:10.1007/BF00591565. PMID 560681. S2CID 8845219.

[13]Stanojilovic OP, Zivanovic DP, Su Sic VT (2002). The effects of Delta Sleep-Inducing Peptide on incidence and severity in metaphit-induced epilepsy in rats. Pharmacological Research. 45 (3): 241–247. doi:10.1006/phrs.2001.0938. PMID 11884222.

[14]Stanojlović O, Zivanović D, Mirković S, Mikhaleva I (February 2004). “Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures”. Pharmacol. Biochem. Behav. 77 (2): 227–34. doi:10.1016/j.pbb.2003.10.014. PMID 14751449. S2CID 25447645.

[15] Sinyukhin AB, Timoshinov GP, Komilov VA, Shabanov PD (2009). Delta sleep-inducing peptide analogue corrects the eNS functional state of children treated with antiblastomic therapy. European Neuropsychopharmacology. 19: S681–S682. doi:10.1016/S0924-977X(09)71101-0. S2CID 54240550.

[16]Schneider-Helmert D (1986). “DSIP in Sleep Disturbances”. Eur Neurol. 25 (2): 154–157. doi:10.1159/000116097. PMID 3758119.

[17]Schneider-Helmert D, Schoenenberger GA (1981). “The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep”. Cellular andMolecular Life Sciences. 37 (9): 913–917. doi:10.1007/BF01971753. PMID 7028502. S2CID 33195794.

[18]Yukhananov RY, Tennila TM, Miroshnichenko II, Kudrina VS, Ushakov AN, Melnik EI (1992). Ethanol and Delta Sleep Inducing Peptide effects on brain monoamines. Pharmacol. Biochem. Behav. 43 (3): 683–687. doi:10.1016/0091-3057(92)90396-W. PMID 1448465. S2CID 54364363.

Author of this article:

Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Inessa I. Mikhaleva

Corresponding author at: Shemyakin–Ovchinnikov Institute of Bioorganic   Chemistry, Russian Academy of Sciences, Peptide Chemistry, ul. 

Elena M. Khvatova

Nizhnii Novgorod Medical Academy, Minina-Pozharskogo 10/1, 603005 Nizhnii Novgorod, Russia

Natalia A. Rubanova

Nizhnii Novgorod Medical Academy, Minina-Pozharskogo 10/1, 603005, Nizhnii Novgorod, Russian Federation

E.Dryzek

Institute of Nuclear Physics, ul. Radzikowskiego 152, Pl-32-431 Kraków, Poland

A.Nakamura

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.

Author of this article:

Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.