Semaglutide

Semaglutide is a naturally occurring derivative of GLP-1, a peptide that has been shown to lower blood sugar levels and enhance insulin secretion. Studies have shown that Semaglutide improves cardiovascular, liver and lung function, while also slowing and preventing the effects of Alzheimer’s disease. Semaglutide works by slowing gastric emptying and reducing intestinal motility to reduce appetite. GLP-1 receptor agonists mimic the incretin glucagon-like peptide (GLP-1) to achieve the goal of lowering blood sugar. It stimulates insulin secretion and inhibits glucagon secretion.

Semaglutide structure

Semaglutide and GLP-1 overview

GLP-1 is a naturally occurring short peptide hormone that reduces blood sugar levels primarily by enhancing insulin secretion. In the gastrointestinal system, GLP-1 significantly reduces appetite by delaying gastric emptying and reducing gastrointestinal motility. besides. GLP-1 affects the heart, fat, blood vessels, muscles, liver, kidneys, etc. The following is the development history of GLP-1:

Discovery of GLP-1 (1980s):

GLP-1 is identified as a peptide hormone with the function of enhancing insulin secretion after food intake.

Scientists discovered GLP-1’s role in glucose metabolism and recognized its potential to treat type 2 diabetes.

Preliminary research on GLP-1 analogues (1990s-21st century):

Researchers set out to develop GLP-1 analogues to improve its stability and efficacy.

Early versions of GLP-1 analogues had shorter half-lives and required frequent injections.

GLP-1 receptor agonists are derivatives of GLP-1 that can remain in the blood longer and have a longer half-life than GLP-1.

How does GLP-1 receptor agonists work?

GLP-1 receptor agonists are derivatives of GLP-1. GLP-1 is a hormone produced by the small intestine that has a variety of effects including:

Promoting the release of insulin: Insulin is an essential hormone in our body that can lower the blood sugar content. Therefore, GLP-1 drugs can be used to control blood sugar levels in type 2 diabetes.

Inhibiting the release of glucagon: Glucagon is a hormone in the body that increases blood sugar levels, so inhibiting the release of glucagon can control the rise in blood sugar.

Slowing down gastric emptying: Another effect of GLP-1 is to slow down gastric emptying, which means it slows down the rate at which food leaves the stomach. This leads to a longer feeling of fullness and helps reduce food intake.

Suppressing appetite: The GLP-1 hormone acts on the brain to reduce appetite, which helps to reduce food intake and calorie intake.

The GLP-1 agonist drug Semaglutide mimics the effects of this hormone. Thereby achieving the purpose of controlling blood sugar and managing weight.

Semaglutide and GLP-1 benefits：

Semaglutide is a GLP-1 drug. Here are the benefits of GLP-1 hormones:

①GLP-1 and type2 diabetes：

Semaglutide works by mimicking the effects of the GLP-1 hormone, helping to regulate blood sugar levels, boosting insulin production, and reducing appetite. Here are some of the benefits people with type 2 diabetes will experience when using Semaglutide:

Blood Sugar Control: Semaglutide (GLP-1 hormone) may help to lower blood sugar levels by stimulating insulin secretion and reducing the amount of glucose produced by the liver when blood sugar levels are high, thereby reducing the risk of hyperglycemia.

Reduced Risk of Cardiovascular Disease: Clinical studies have demonstrated that Semaglutide (GLP-1 hormone) reduces the risk of major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death, in patients with diabetes and cardiovascular disease.

Weight Loss: Many individuals with type 2 diabetes experience weight loss while taking Semaglutide (GLP-1 hormone), which is beneficial because weight management is a crucial aspect of diabetes control.

②GLP-1 and weight management：

In addition to being used for blood sugar control in type 2 diabetes, GLP-1 can also be used for weight management.

Effect Weight Loss: Studies have demonstrated that Semaglutide (GLP-1 hormone) drugs are an effective treatment for weight loss in patients who are obese or overweight (even without diabetes). Clinical trials have demonstrated that patients have experienced significant weight loss.

Appetite Suppression: Semaglutide (GLP-1 hormone) helps to reduce appetite, which in turn reduces calorie intake and, as a result, weight loss.

Improved Metabolic Health: Improved metabolic health is another notable benefit of Semaglutide (GLP-1 hormone). Semaglutide’s ability to assist with weight loss can also improve metabolic parameters such as cholesterol levels, blood pressure, and inflammatory markers.

Reduced Risk of Weight-Related Diseases: Semaglutide(GLP-1 hormone) has been shown to reduce the risk of weight-related diseases. A reduction in excess weight can help to mitigate the risk of obesity-related diseases, including type 2 diabetes, cardiovascular disease and certain cancers.