Best FOXO4-DRI powder Peptides GMP Factory

FOXO4-DRI powder

FOXO4-DRI powder

Other names:Forkhead box O transcription factor 4-D-Retro-Inverso, Proxofim, D-Retro Inverso Forkhead box protein O4, FOXO4-D-retro-inverso

FOXO4-D-Retro-Inverso(DRI) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.

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Referenced Citations

[1]Parry P, Wei Y, Evans G (Feb 1995). “Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family”. Genes Chromosomes Cancer. 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552. S2CID 19965473. 

[2]Weigel D, Jäckle H (Nov 1990). “The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?”. Cell. 63 (3): 455–456. doi:10.1016/0092-8674(90)90439-l. PMID 2225060. S2CID 1986657.

[3]van der Horst A, Burgering BM (Jun 2007). “Stressing the role of FoxO proteins in lifespan and disease”. Nature Reviews Molecular Cell Biology. 8 (6): 440–450. doi:10.1038/nrm2190. PMID 17522590. S2CID 31546098.

[4]Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A (Aug 2005). “Acetylation of Foxo1 alters its DNA-binding ability and sensitivityto phosphorylation”. Proceedings of the National Academy of Sciences of the United States of America. 102 (32): 11278–11283.Bibcode: 2005PNAS..10211278M. doi:10.1073/pnas.0502738102. PMC 1183558. PMID 16076959.

[5]Boura E, Silhan J, Herman P, Vecer J, Sulc M, Teisinger J, Obsilova V, Obsil T (Mar 2007). “Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding”. The Journal of Biological Chemistry. 282 (11): 8265–8275. doi:10.1074/jbc.M605682200. PMID 17244620. S2CID 22561455.

[6]Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M (Oct 2008). “SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans”. Genes & Development. 22 (19): 2721–2735.

[7]Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD (Sep 2008). “FOXO3A genotype is strongly associated with human longevity”. Proceedings of the National Academy of Sciences of the United States of America. 105 (37): 13987–13992. Bibcode:2008PNAS..10513987W. doi:10.1073/pnas.0801030105. PMC 2544566. PMID 18765803.

[8]Baar MP, Brandt RM, Putavet DA, Klein JD, Derks KW, Bourgeois BR, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RW, Madl T, Hoeijmakers JH, Campisi J, de Keizer PL (2017). “Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging”. Cell. 169 (1): 132–147. doi:10.1016/j.cell.2017.02.031. PMC 5556182. PMID 28340339.

[9]Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (Apr 2004). “High frequency of mutations of the PIK3CA gene inhuman cancers”. Science. 304 (5670): 554. doi:10.1126/science.1096502. PMID 15016963. S2CID 10147415.

[10]Yang H, Zhao R, Yang HY, Lee MH (Mar 2005). “Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity”. Oncogene. 24 (11): 1924–35. doi:10.1038/sj.onc.1208352.PMID 15688030. S2CID 20360440.

[11]Liu X, Zhang Z, Sun L, Chai N, Tang S, Jin J, Hu H, Nie Y, Wang X, Wu K,Jin H, Fan D (Dec 2011). “MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4”. Carcinogenesis. 32 (12): 1798–1805. doi:10.1093/carcin/bgr213. PMID 21934092.

[12]Liu X, Zhang Z, Sun L, Chai N, Tang S, Jin J, Hu H, Nie Y, Wang X, Wu K, Jin H, Fan D (Dec 2011). “MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4”. Carcinogenesis. 32 (12): 1798–1805. doi:10.1093/carcin/bgr213. PMID 21934092.

[13]Brenkman AB, de Keizer PL, van den Broek NJ, van der Groep P, van Diest PJ, van der Horst A, Smits AM, Burgering BM (Sep 2008). “The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors”. Cancer Res. 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148.

[14]Brenkman AB, de Keizer PL, van den Broek NJ, Jochemsen AG, Burgering BM (2008). Cookson MR (ed.).“Mdm2 induces mono-ubiquitination of FOXO4”. PLOS ONE. 3 (7): e2819. Bibcode:..3.2819Bdoi:10.1371/journal.pone.0002819PMC 2475507PMID 18665269.

[15]Wong D, Yip S (April 2020).“Making heads or tails – the emergence of capicua (CIC) as an important multifunctional tumour suppressor”. The Journal of Pathology. 250 (5): 532–540. doi:1002/path.5400PMID 32073140S2CID 211192274.

Author of this article:

Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

  1. Guihua Liu Ph.D.

The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 

  1. XingYang Ph.D.

The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

  1. TingtingLi

Reproductive Medicine Research Center, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

  1. Hillary H. Le

Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, USA

  1. Utkarsh Tripathi

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.

Author of this article:

Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.