Kisspeptin-10 Powder
specification: Kisspeptin-10 5MG, Kisspeptin-10 10MG
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Properties
Description
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Properties
Sequence: | YNWNSFGLRF |
Molecular Formula: | C63H83N17O14 |
Molecular Weight: | 1302.4 g/mol |
PubChem CID: | 25240297 |
CAS Number: | 374675-21-5 |
Synonyms: | Kisspeptin-10, 374675-21-5, Kisspeptin-10 (human) Metastin (45-54), KP-10 |
Description
What is Kisspeptin-10?
Kisspeptin, also known as metastin, is a naturally occurring protein in humans that serves crucial roles in hormone signaling, particularly during puberty and reproduction. Additionally, it is believed to impact mood and behavior, facilitate angiogenesis, and regulate kidney function. The peptide has been discovered in the brain and has demonstrated the ability to inhibit tumor growth and metastasis. Of significant scientific interest is its influence on gonadotropin-releasing hormone (GnRH).[1][2]
Kisspeptin-10 Structure
Authoritative source:Pubchem
What is Kisspeptin-10?
Kisspeptin is a potent neuropeptide released by the hypothalamus that stimulates and triggers the secretion of gonadotropin-releasing hormone. It plays an important role in human reproduction, aldosterone secretion (regulation of water-salt balance), tumor suppression and renal function. Kisspeptin-10, sometimes called KP-10, is the strongest and most potent member of the kisspeptin peptide family. Research has shown that kisspeptin plays an important role in the early stages of reproductive development..
How Does Kisspeptin-10 work?
Kisspeptin functions by interacting with G-protein-coupled receptors (GPCRs). This, in turn, promotes the production of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex steroids. LH, FSH, and sex steroids encourage the development of reproductive cells such as eggs and sperm in the gonads. Kisspeptin raises testosterone levels via influencing the levels of the hormones LH and FSH in the blood..
What are the benefits of kisspeptin-10?
❶ Kisspeptin-10 and Increases Testosterone Levels.
Kisspeptin administration has been associated with increased LH, FSH, and testosterone concentrations in male volunteers and rats.
Kisspeptin may have implications for reproductive health, bone health, cognitive function, and fat distribution.
❷ Kisspeptin-10 and Lowers the Risk of Heart Disease.
Kisspeptin has shown potential cardioprotective properties by improving blood flow to the heart and reducing the risk of heart injury.[3[4]
❸ Kisspeptin-10 and Boosts Immunity.
Kisspeptin has been linked to immune-modulating effects, including antiviral effects and integration of reproductive and immune functions during pregnancy.
❹ Kisspeptin-10 and Helps Lose Weight.
Some studies suggest that kisspeptin could potentially aid in weight loss by reducing food intake and combating diet-induced obesity.
❺ Kisspeptin-10 and Prevents Wrinkles and Skin Aging.
Kisspeptin may have a role in improving UV-induced skin aging and could be considered as a therapeutic option for sun-damaged skin.
❻ Kisspeptin-10 and Prevents Cancer.
Various studies indicate that kisspeptin might exert anti-cancer effects, inhibiting proliferation, migration, and invasion of cancer cells across different types of cancer.[15]
❼ Kisspeptin-10 and Boosts Brain Power.
Kisspeptin has been linked to brain function enhancement, including emotional processing, response to attraction cues, and sexual and emotional brain processing.
❽ Kisspeptin-10 and Treats Fertility Disorders.
Kisspeptin appears to be involved in regulating fertility by affecting gonadotropin-releasing hormone (GnRH) production, ovulation activation, and hormone release.
Side Effects of Kisspeptin-10
Kisspeptin side effects are quite rare. There have been several negative effects connected with the usage of this medicine, with the patient experiencing one of the problems listed below at some time while on kisspeptin. However, these adverse effects were not proven to be connected with the medication and might have been a coincidence unrelated to kisspeptin usage. Despite this, it was labeled as a kisspeptin side effect, despite the fact that these linked side effects are extremely rare.[5][6]
Side effects of kisspeptin may include the following:
- Diarrhea
- Sweating excessively
- Headache
- Flushes of heat
- Postural vertigo
- Menstrual cycle has been shortened.
Forms of Kisspeptin-10
Kisspeptin-10 is typically administered through intravenous injection. Kisspeptin pills are also available from some vendors.
Best Time To Take Kisspeptin-10
Kisspeptin, like other supplements, should be taken with food. Most people recommend taking Kisspeptin-10 with the first meal of the day, ideally during breakfast.
Kisspeptin-10 vs. Other Compounds
❶ HCG vs. Kisspeptin-10
Kisspeptin-10 and HCG stimulate the production of human gonadotropins. Kisspeptin-10, on the other hand, has long been considered more useful than HCG in protecting against conditions such as testicular atrophy.[7][8]
Kisspeptin-10 is also known to maintain testosterone levels better than human chorionic gonadotropin (HCG). It does this by interacting with the pituitary gland to stimulate testosterone production, which increases sperm count.
❷ Gonadorelin vs. Kisspeptin-10
Both kisspeptin-10 and Gonadorelin have been implicated in reproductive physiology. Kisspeptin-10 is a hypothalamic neuropeptide that promotes the production of GnRH, which leads to the release of LH and FSH.[13][14]
Gonadorelin, on the other hand, is an analogue of GnRH. Therefore, exogenous injection of gonadorelin can directly stimulate LH and FSH secretion.
Kisspeptin-10 Dosage
Kisspeptin dose should be recommended differently for various persons based on their medical circumstances.[9][10]
To get the appropriate dose for you, you should conduct complete blood testing that includes your current FSH and LH levels. It is also advised that you perform the tests for a while to determine the frequency of variation connected with the two hormones.
Compare your findings to the reference hormone levels and see your doctor to determine if and how long you should take the Kisspeptin supplement.
Some experts believe that 10mg and 5mg of Kisspeptin-10 are safe to use on a regular basis.
Kisspeptin-10 Cycle
Avoid consuming Kisspeptin-10 for more than four months in a row. After completing one cycle, you must take a 25-day rest before beginning another.[11][12]
Manufacturers/Factory
Kisspeptin plays a crucial role in regulating hormone secretion, particularly in relation to reproductive functions. And it has the ability to influence testosterone levels and impact sex-related behaviors. If you are looking for the professional and top peptide Kisspeptin manufacturer or factory, here is the right place where you are.
As the best Kisspeptin acetate peptide manufacturer, peptide.ltd is not only supply the peptide Kisspeptin acetate in powder form but provide the customized standard easy use vial form.
You can buy the best price Kisspeptin acetate and best quality peptide from this professional peptide manufacturer.
Coa & MS
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It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.Can I Appoint The kisspeptin Packaging Colour When Buy kisspeptin?
YES! peptide.ltd as peptide manufacturer, provide Packaging colour customization of kisspeptin, easy to help you to build your kisspeptin peptide brand.Can I Appoint The Products Standard When Buy kisspeptin From peptide.ltd?
YES! As one of the best kisspeptin manufacturer, peptide.ltd not only provide the standard specification of kisspeptin in 5mg, 10mg, but support standard customization. Provide the best support to build your own kisspeptin brand.Can I Buy kisspeptin In Pure Powder Form From peptide.ltd?
YES! kisspeptin powder is the base that use for kisspeptin lyophilized powder manufacture. peptide.ltd provide kisspeptin in both of pure powder form and semi-finished vial form.Can I Buy Discount kisspeptin Powder From peptide.ltd?
YES! Our factory produce high quality kisspeptin powder in term and keep kisspeptin powder in stock. You can buy high quality kisspeptin powder in bulk. During promotion sale, you can buy kisspeptin peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk kisspeptin price for you in time.FAQ
Is Kisspeptin a testosterone booster?
Yes, exogenous Kisspeptin-10 inclusion can boost testosterone levels in men. Kisspeptin-10 promotes the body to manufacture testosterone in balanced proportions, preventing levels from getting excessively high.
What role does Kisspeptin play in males?
According to study, continuous infusion of Kisspeptin-10 in men can result in an increase in LH, testosterone, LH pulse frequency, and pulse size.
Is Kisspeptin a testosterone booster?
Yes, exogenous Kisspeptin-10 inclusion can boost testosterone levels in men. Kisspeptin-10 promotes the body to manufacture testosterone in balanced proportions, preventing levels from getting excessively high.
What role does Kisspeptin play in males?
According to study, continuous infusion of Kisspeptin-10 in men can result in an increase in LH, testosterone, LH pulse frequency, and pulse size.
Is Kisspeptin-10 effective in increasing sperm count?
There hasn’t been a lot of studies that shows an increase in sperm count. It does, however, imply a possible influence on sperm motility in normozoospermic patients.
Does Kisspeptin cause a rise in FSH?
Kisspeptin stimulates the hypothalamic release of gonadotropin-releasing hormone. GnRH, in turn, stimulates the release of reproductive hormones such as LH and FSH from the anterior pituitary gland’s gonadotrophs.
Is Kisspeptin necessary for puberty?
Kisspeptin-10 and its receptor are essential for the hypothalamus-pituitary-gonadal axis to operate properly. In this sense, it is critical to regulate the start of puberty in animals.
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Kisspeptin-10 Peptide Dosage Calculator
Referenced Citations
[1]GRCh38: Ensembl release 89: ENSG00000170498 – Ensembl, May 2017
[2]GRCm38: Ensembl release 89: ENSMUSG00000116158 – Ensembl, May 2017
[3]National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (December 1996). “KiSS-1, a novel human malignant melanoma metastasis-suppressor gene”. Journal of the National Cancer Institute. 88 (23): 1731–7. doi:10.1093/jnci/88.23.1731. PMID 8944003.
[6]Skorupskaite K, George JT, Anderson RA (2014). The kisspeptin-GnRH pathway in human reproductive health and disease. Human Reproduction Update. 20 (4): 485–500.
[7]Pasquier J, Kamech N, Lafont AG, Vaudry H, Rousseau K, Dufour S (June 2014). “Molecular evolution of GPCRs: Kisspeptin/kisspeptin receptors”. Journal of Molecular Endocrinology. 52 (3): T101-17. doi:10.1530/JME-13-0224. PMID 24577719.
[8]Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (December 1996). “KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene”. Journal of the National Cancer Institute. 88 (23): 1731–1737. doi:10.1093/jnci/88.23.1731. PMID 8944003.
[9]Takahashi K, Shoji I, Shibasaki A, Kato I, Hiraishi K, Yamamoto H, Kaneko K, Murakami O, Morimoto R, Satoh F, Ito S, Totsune K (May 2010). “Presence of kisspeptin-like immunoreactivity in human adrenal glands and adrenal tumors”. Journal of Molecular Neuroscience. 41 (1): 138–144. doi:10.1007/s12031-009-9306-4. PMID 19898965. S2CID 36407231.
[10]Mead EJ, Maguire JJ, Kuc RE, Davenport AP (August 2007). “Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system”. British Journal of Pharmacology. 151 (8): 1143–1153. doi:10.1038/sj.bjp.0707295. PMC 2189831. PMID 17519946.
[11]Lee DK, Nguyen T, O’Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O’Dowd BF (March 1999). “Discovery of a receptor related to the galanin receptors”. FEBS Letters. 446 (1): 103–107. doi:10.1016/S0014-5793(99)00009-5. PMID 10100623.
[12]Rønnekleiv OK, Kelly MJ (2013). “Kisspeptin excitation of GnRH neurons”. Advances in Experimental Medicine and Biology. 784: 113–131. doi:10.1007/978-1-4614-6199-9_6. ISBN 978-1-4614-6198-2. PMC 4019505. PMID 23550004.
[13]Arai AC (January 2009). “The role of kisspeptin and GPR54 in the hippocampus”. Peptides. 30 (1): 16–25. doi:10.1016/j.peptides.2008.07.023. PMID 18765263. S2CID 33934227.
[14]Smith JT, Clarke IJ (March 2007). “Kisspeptin expression in the brain: catalyst for the initiation of puberty”. Reviews in Endocrine & Metabolic Disorders. 8 (1): 1–9. doi:10.1007/s11154-007-9026-4. PMID 17334929. S2CID 9496307.
[15]Thurston L, Hunjan T, Ertl N, Wall MB, Mills EG, Suladze S, et al. (October 2022). Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open. 5 (10): e2236131
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, Spain
Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain
3.Kui Ding
CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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