Best GHK-Cu 5mg and 10mg Peptides GMP Factory

GHK-Cu

GHK-Cu

Other names:Glycyl-L-Histidyl-L-Lysine; Growth Regulatory Peptide; Colaren; Hepatocyte Growth Factor; Hepatic Growth Factor Cu-GHK; Glycyl Histidyl Lysine, Monocopper Salt

GHK-Cu, also known as blue copper peptide and tripeptide-1 copper, is a tripeptide composed of three amino acids glycyl-L-histidyl-L-lysine and a copper ion (Cu2+). Known for its binding to copper ions (Cu2+), GHK was first isolated from human plasma in 1970 by American scientists Pickart et al. The concentration of plasma GHK is significantly related to the regeneration ability of the body. Studies have shown that the concentration of GHK-Cu in the plasma of 20-year-old people is about 2.5 times that of 60-year-old people. GHK-Cu is believed to have various benefits, especially in the areas of skin care and wound healing.

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Referenced Citations

[1]Pickart, L; Thaler, MM (1973). “Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver”. Nature New Biology. 243 (124): 85–87. PMID 4349963

[2]Pilgeram, L; Pickart, L (1968). Control of fibrinogen biosynthesis; the role of free fatty acids”. Journal of Atherosclerosis Research. 8 (1): 155–166. doi:10.1016/s0368-1319(68)80089 -4. PMID 5642099

[3]Pickart, L (1973), A tripeptide in human plasma that increases the survival of hepatocytes and the growth of hepatoma cells, Ph.D. Thesis in Biochemistry: University of California, San Francisco

[4]Schlesinger, DH; Pickart, L; Thaler, MM (1977). “Growth-modulating serum tripeptide is glycyl-histidyl-lysine”. Cellular and Molecular Life Sciences. 33 (3): 324–325. doi:10.1007/BF02002806. PMID 858356. S2CID 29422959.

[5]Pickart, L; Freedman, JH; Loker, WJ; et al. (1980). “Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells”. Nature. 288 (5792): 715–717. Bibcode:1980Natur. 288..715P. doi:10.1038/288715a0. PMID 7453802. S2CID 4304271

[6]Maquart, FX; Pickart, L; Laurent, M; Gillery, P; Monboisse, JC; Borel, JP (1988). “Stimulation of collagen synthesis in fibroblast cultures by the tripleptide-copper complex glycyl-L-histidyl-L-lysine -Cu2+”. FEBS Letters. 238 (2): 343–6. doi:10.1016/0014-5793(88)80509-x. PMID 3169264. S2CID 19289897

[7]Wegrowski, Y.; Maquart, F.X.; Borel, J.P. (1992). “Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex Glycyl-L-histidyl-L-lysine-Cu2+”. Life Sciences. 51 (13): 1049 –1056. doi:10.1016/0024-3205(92)90504-i. PMID 1522753

[8]Maquart, FX; Bellon, G; Pasco, S; Monboisse, JC (2005). “Matrikines in the regulation of extracellular matrix degradation”. Biochimie. 87 (3–4): 353–60. doi:10.1016/j.biochi .2004.10.006. PMID 15781322

[9]Siméon, A; Wegrowski, Y; Bontemps, Y; Maquart, FX (2000). “Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+ )”. The Journal of Investigative Dermatology. 115 (6): 962–8. doi:10.1046/j.1523-1747.2000.00166.x. PMID 11121126

[10]Siméon, Alain; Emonard, Hervé; Hornebeck, William; Maquart, François-Xavier (2000). “The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures”. Li fe Sciences. 67 (18): 2257–2265. doi:10.1016/s0024-3205(00)00803-1. PMID 11045606

[11]Gul, NY; Topal, A; Cangul, IT; Yanik, K (2008). “The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits”. Veterinary Dermatology. 19 (1): 7–14 .doi:10.1111/j.1365-3164.2007.00647.x. PMID 18177285

[12Pickart L. Compositions for accelerating wound healing in mammals containing cupric salt or complexes with amino acid or peptide. US Patent 5,164,367, 1992.

[13]Kartha, R; Jayakumar, R (2007). “A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices”. Life Sciences. 80 (4): 275–84. doi:10.1016/j.lfs.2006.09.018 . PMID 17049946

[14]Gorouhi, F.; Maibach, H.I. (2009). “Role of topical peptides in preventing and treating aged skin. International Journal of Cosmetic Science. 31(5): 327–345. doi:10.1111/j.1468-2494.2009. 00490.x. PMID 19570099. S2CID 20558453

[15]Pickart-Margolina (2018). “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data”. International Journal of Molecular Sciences. 19 (7): 7. doi:10.3390/ijms19071987. PMC 6073405. PMID 29986520.

Author of this article:

Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

scientific journal paper author: 1.Jinzhen Huang School of Physics and  Optoelectronics, South China University of Technology, Guangzhou 510640, China 2.Yan Pan Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506-6045, United States 3.Yan Yin Department of Respiratory and Critical Care Medicine, First Hospital of China Medical University, No.155, Nanjing North Street, Shenyang, China 4.Dilara Z. Gatina Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia 5.Spyros Vernardis Biological Systems Engineering Laboratory, Department of Chemical Engineering & Chemical Technology, Imperial College London, London, UK In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. peptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.

Author of this article:

Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.