GHK-Cu
Other names:Glycyl-L-Histidyl-L-Lysine; Growth Regulatory Peptide; Colaren; Hepatocyte Growth Factor; Hepatic Growth Factor Cu-GHK; Glycyl Histidyl Lysine, Monocopper Salt
GHK-Cu, also known as blue copper peptide and tripeptide-1 copper, is a tripeptide composed of three amino acids glycyl-L-histidyl-L-lysine and a copper ion (Cu2+). Known for its binding to copper ions (Cu2+), GHK was first isolated from human plasma in 1970 by American scientists Pickart et al. The concentration of plasma GHK is significantly related to the regeneration ability of the body. Studies have shown that the concentration of GHK-Cu in the plasma of 20-year-old people is about 2.5 times that of 60-year-old people. GHK-Cu is believed to have various benefits, especially in the areas of skin care and wound healing.
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Properties
Description
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Properties
Sequence : |
Gly-His-Lys(Cu |
Molecular Formula : |
C14H24N604 |
Molecular Weight : |
340.38g/mol |
PubChem CID: |
342538 |
CAS Number: |
49557-75-7 |
Synonyms: | GHK Copper peptide; L-Lysine, Glycyl-L-Histidine-; Copper Peptide Powder(GHK-cu);GHK Copper Copper Peptide GHK.Cu GHK-Cu;Ahk-cu; Hepatocyte Growth Factor (GHK); GHKcu/growth-regulated peptide; (Gly-His-Lys)2Cu.xHAc |
Description
GHK-Cu Peptide Structure
Authoritative source:PubChem
Authoritative source:PubChem
What Is GHK-Cu Peptide?
GHK-Cu, also known as GHK-Copper or simply GHK-Cu, copper peptide GHK-Cu is a natural copper complex of the tripeptide glycyl-L-histidyl-L-lysine. Copper peptides are generally small, naturally occurring protein fragments. It has a strong affinity for copper(II) and was first found in human plasma. The existence of copper ions plays a very important role and function in the life activities of various organisms in nature, including cellular respiration, antioxidant defense, connective tissue formation and blood coagulation. GHK-Cu is also found in different parts of the body, such as saliva and urine, and there is evidence that it is essential for normal physiological function.[1][2]
GHK-Cu is the first peptide discovered by humans to have cosmetic effects, so it is called “the ancestor of peptides”. It is the latest generation of high-tech micro-peptides composed of three amino acids and one copper ion. Its color is not the yellow of metallic copper, but blue, hence the name blue copper peptide. As early as 1970, a team of American biochemical technology experts discovered through research that blue copper peptide can not only accelerate wound healing, but also reduce the formation of scar tissue, which is very effective in treating skin injuries. In addition to this, GHK-Cu has multiple activities in the human body, including attracting immune cells, anti-oxidation and anti-inflammation, increasing collagen and glycosaminoglycan production in skin fibroblasts, and promoting blood vessel development.
GHK-Cu has many other advantages: (1) Stimulate the formation of collagen and elastin, tighten loose skin, reverse the thinning of aging skin, and repair the protective skin barrier protein; (2) Restore skin repair ability, increase The production of mucus between skin cells improves the structure of aging skin, smoothes rough skin, and reduces skin damage; (3) Stimulates the formation of glucosamine, increases skin thickness, reduces skin relaxation, and tightens the skin. Therefore, the importance of GHK-Cu is self-evident. It successfully stands out from many peptides and becomes an upstart in the field of skin care products. GHK-Cu is mild in nature, and also has multiple functions such as anti-aging, repairing, anti-wrinkle, inhibiting hair loss, and anti-free radicals. If you want to buy high-quality GHK-Cu peptides for research and use, please be sure to buy them from regular peptide manufacturers.
What are the benefits of GHK-Cu peptide?
- Targeting skin health:GHK-Cu has received extensive attention from the skin care industry for its potential to promote collagen production, promote wound healing, and improve skin elasticity. It may help reduce the appearance of fine lines and wrinkles and aid in overall skin rejuvenation.
- Has anti-inflammatory properties: The potential anti-inflammatory effects of GHK-Cu have been studied. It may help regulate inflammation and promote tissue repair, making it a potential candidate for addressing various inflammatory skin diseases. GHK-Cu can be used as systemic injection or topical application therapy to treat inflammatory skin diseases such as psoriasis. Studies have also shown that it reduces redness caused by ultraviolet sunlight.[3][4]
- Hair growth:Some studies have shown that GHK-Cu can promote hair growth and reduce hair loss. It is often added to hair sprays and shampoos along with other copper peptides to restore hair growth. Likewise, it is thought to stimulate hair follicles and improve the overall health of the scalp. Within the hair follicle, GHK-Cu has been shown to boost collagen production and strengthen existing hair by stimulating growth in areas lacking thickness.
- Wound healing and tissue remodeling activity: The potential of GHK-Cu to promote wound healing is attributed to its ability to promote collagen synthesis, regulate inflammation, and stimulate cell migration involved in tissue repair. During wound healing, it results in better wound contraction, faster development of granular tissue, and improved angiogenesis to restore blood flow to damaged tissue. Research has also shown that systemic injections of GHK-Cu can also boost the healing process. Injection of GHK-Cu into muscle promotes distal tissue repair.
- Antioxidant properties: Copper peptides (including GHK-Cu) are believed to have antioxidant properties that help protect cells from oxidative stress and damage.
- Treatment of acute lung injury through immune cell modulation:GHK-CU showed potential benefits in the treatment of acute lung injury by modulating immune cell activity. This modulation helps to lessen the damaging effects of inflammation and promotes a more controlled healing response, resulting in improved recovery outcomes.
- Promotes Nerve Growth to Support Nervous System Function: GHK-Cu may benefit cognitive health by playing a role in nerve regeneration, thereby contributing to the overall support of nervous system function. By promoting nerve growth and repair, this peptide can help address various neurological disorders and maintain optimal neurological health. A study on the effect of GHK-Cu on neuronal axons showed that it can increase the migration of blood-derived cells to collagen tubes, produce nerve growth factors, increase the expression of integrins, and increase the regeneration rate of nerve cells. myelinated nerve fibers. Schwann cell and axon counts also increased.
- DNA Repair and Antiaging Properties: The multifaceted nature of GHK-CU extends to its effects on DNA repair mechanisms and general antiaging properties. It further enhances its versatility as a powerful peptide by protecting DNA from damage and promoting c-cell health. GHK-Cu significantly improves the appearance of aging skin, increases thickness, reduces wrinkles, and strongly induces dermal keratinocyte proliferation.[5][6]
- Anticancer: GHK-Cu has been recommended as a treatment for metastatic cancer. The research determines gene expression in normal and cancer cells and finds out which substances can silence genes involved in metastasis. Using a database containing the expression profiles of 7,000 genomes, they found that only 2 overexpressed genes were effective in reducing tumor spread after treatment with 1,309 bioactive substances; one of them was GHK-Cu. Gene manipulation is an exciting field in medicine, especially in the field of cancer treatment.
- Reduce pain, anxiety and aggression: GHK-Cu can help you reduce anxiety and improve pain tolerance. This is exciting news for anyone considering GHK-Cu peptide therapy, as some animal studies suggest it could do so at very low doses if scaled up for human use. Ideally, you can achieve these benefits with GHK-Cu injections.[7][8]
Specific Benefits of GHK-CU for Skin Health and Hair Growth
- Enhances collagen production, improving skin firmness, density and overall appearance
A notable benefit of GHK-CU is its ability to boost collagen production, which improves skin’s firmness, density, and overall appearance. Increased collagen synthesis helps maintain skin’s elasticity and youthful glow.
- Reduces Wrinkles, Age Spots and Mottled Hyperpigmentation
The use of GHK-CU has been shown to reduce common signs of aging such as wrinkles, age spots and uneven pigmentation. By addressing these issues at the cellular level, it helps create a more even, radiant complexion.
- Anti-inflammatory for sensitive or damaged skin
Sensitive or damaged skin can also benefit from the anti-inflammatory properties of GHK-CU. Its soothing action helps reduce irritation and promote faster recovery of problem areas.
- Supports healthy blood vessels and tissue repair processes
GHK-CU supports healthy blood vessels and the tissue repair process by stimulating angiogenesis (the formation of new blood vessels) and promoting cell regeneration. Through these combined actions, it actively contributes to the maintenance of overall skin health and vitality.[9][10]
- Stimulate hair follicles to promote growth
GHK-CU plays a vital role in promoting hair growth by stimulating the hair follicle at the cellular level. This activation allows for healthier, stronger hair growth for a fuller appearance.
- Improves the health and strength of hair strands
In addition to stimulating hair follicle activity, GHK-CU contributes to the overall health and strength of each strand. Helps create the optimal environment for keeping hair strong and vibrant by nourishing the scalp and supporting collagen production.
- Can reverse hair loss by increasing collagen production around hair follicles
GHK-CU addresses hair loss by increasing collagen production around the base of the hair follicle. This action provides the necessary support for the structural integrity of the hair follicle, potentially reversing or minimizing hair loss due to age or other factors.[11][12]
GHK-Cu Mechanism of Action
GHK-Cu acts as a chemoattractant for various immune cells, such as mast cells and macrophages, to the site of tissue injury. These immune cells release proteins that stimulate tissue growth and repair, aiding the healing process. First, it acts directly on fibroblasts by increasing mRNA and protein production of collagen, elastin, proteoglycans, glycosaminoglycans and decorin. By increasing the production of these components, GHK-Cu supports tissue repair and maintenance. In addition, it stimulates the production of metalloproteinases and protease inhibitors. Metalloproteases help break down damaged tissue proteins, while protease inhibitors prevent excessive degradation and maintain a balanced tissue remodeling process. In the process, it also reduced the secretion of TGF-beta, a cytokine that promotes scarring, from fibroblasts. Helps prevent excessive scar tissue formation by reducing the secretion of scar tissue. GHK-Cu can also enhance collagen synthesis in chondrocytes in bone tissue. This results in increased growth of human bone marrow stromal cells and increased attachment of osteoblasts, thereby promoting bone growth and formation. It also provides a source of copper to blood vessels during tissue angiogenesis. The presence of GHK-Cu in growing tissues is essential for survival because angiogenesis cannot occur without proper copper depots. It provides a source of copper, the proper level of which is required for angiogenesis to occur. The study also showed that GHK-Cu was able to increase axonal differentiation and proliferation within neurons, suggesting a potential role in maintaining normal nervous system function. GHK-Cu blocks ferritin channels and the release of tissue-damaging free (oxidized) iron after tissue injury, thereby blocking iron-catalyzed lipid peroxidation that occurs after injury. This action helps prevent iron-catalyzed lipid peroxidation.[13][14]
GHK-Cu Side Effects
GHK-Cu is a naturally occurring substance in the body and The application of GHK-Cu in the cosmetic and medical fields is relatively new. Therefore, little research has been done on possible side effects. Research suggests some possible side effects include:
- Headache
- fatigue
- Dizziness
- nausea
- redness/pain at the injection site
- Skin allergies
- increased appetite
- Hypertension
The researchers estimated that the lethal dose of GHK-Cu was about 330 mg/kg of body weight, more than 300 times higher than the known effective dose. Nonetheless, this data point needs to be kept in mind when designing studies
However, one of the best parts about this peptide is that it is naturally produced in the body, allowing your system to welcome GHK and utilize it. One of the most important parts of reducing any possible side effects is making sure you are taking the correct dosage.
Is GHK-Cu injection safe?
Despite GHK-Cu’s favorable safety profile, the subcutaneous or intramuscular administration of peptides in general is associated with injection site pain, lightheadedness, nausea, and even flu-like symptoms in subjects.If you’re considering getting an injection, discussing the possibility with your healthcare provider is an excellent first step on the journey to start this revolutionary treatment. One of the most important parts of GHK-Cu Injections is making sure you are getting them from a reliable, safe source. When you get GHK-Cu Injectable Peptides through peptide.ltd, you can rest assured that you are getting the best quality GHK-Cu Peptides.
GHK-Cu For Sale | GHK-Cu Supplier
GHK-Cu is a small peptide molecule with multiple potential benefits, including optimizing mitochondrial function, enhancing energy production, improving metabolic health, and regulating glucose and lipid metabolism. It shows promise in controlling obesity and diabetes, promoting muscle health and delaying the aging process. Further research is needed to fully understand and exploit its therapeutic potential. Researchers interested in GHK-Cu experiments want to make sure they are sourcing this material from a reliable supplier. If you’re looking to buy GHK-Cu online, proceed with caution and make sure you’re getting the peptides from a reputable and trustworthy manufacturer. peptide.ltd is a highly reliable manufacturer of pharmaceutical grade peptides.[15]
Manufacturers/Factory
GHK-CU is special in that it is a special type of peptide, a copper-based peptide. GHK is the scientific abbreviation for peptide, and CU is the name of copper in the periodic table; therefore, it is called GHK-CU copper peptide. Its effects on various diseases have been gradually discovered and reported. If you are looking for a professional, high-quality Peptide GHK-Cu manufacturer or factory, here is your right choice.
Amino acids are natural building blocks of the human body and are vital in many natural processes. That’s why GHK-CU gets so much hype. It is said to improve the way the body produces collagen and elastin, keeping our skin looking youthful, vibrant and wrinkle-free. As we age, we lose collagen, the substance that makes our skin look clear and plump, and elastin, the compound that keeps skin smooth and wrinkle-free. As we age, we lose both substances and our bodies produce less of both. It is very necessary for the body to obtain a certain amount of GHK-CU,
As the best GHK-CU Peptide manufacturer, peptide.ltd not only offers Peptide GHK-CU in powder form but also in customized standard easy-to-use vial form.
You can buy GHK-CU at the best price and best quality peptides from this professional peptide manufacturer.
Coa & MS
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What are the advantages of buying GHK-Cu from peptide.ltd?
1) Competitive factory price – factory direct sales, no middleman to earn the difference. 2) Customized service – product specifications can be customized to create your own peptide brand. 3) Quality Assurance – A professional lab report is shipped with the shipment. 4) Fast Shipping-Professional logistics customized solutions, on-time delivery. 5) Convenient payment – various payment methods. 6) 365/24/7 service – high-quality pre-sales and after-sales service, follow-up product and order details consultation.How to quickly get the price of GHK-Cu online?
1) Visit peptide.ltd, a professional GHK-Cu supplier, and select the GHK-Cu you want to buy. 2) Leave your contact information and information on the peptide.ltd website, and then submit to peptide.ltd. 3) The customer service will reply you within 12 hours after receiving your information, and then discuss the purchase of GHK-Cu in detail.Does peptide.ltd support free samples of GHK-Cu?
Depending on the situation, different product policies are different, please consult our customer service. Samples are acceptable for most products.Can I specify the GHK-Cu color when purchasing GHK-Cu?
Yes! peptide.ltd, as a peptide manufacturer, provides GHK-Cu color customization, easily helping you create GHK-Cu peptide brand.Can I specify the product standard when buying GHK-Cu from peptide.ltd?
Yes! As one of the best GHK-Cu manufacturers, Peptide Co., Ltd. not only provides 5mg, 10mg GHK-Cu standard specifications, but also supports standard customization. Provide the best support for building your own GHK-Cu brand.Can I buy GHK-Cu in pure powder form from peptide.ltd?
Yes! GHK-Cu powder is the basis for the manufacture of GHK-Cu freeze-dried powder. peptide.ltd supplies GHK-Cu in pure powder form and semi-finished vial form.Can I buy discounted GHK-Cu powder from peptide.ltd?
Yes! Our factory produces high-quality GHK-Cu powder for a long time, and has GHK-Cu powder in stock. You can buy high quality GHK-Cu powder in bulk. During the promotion period, you can buy GHK-Cu peptide at a lower price. You can keep in touch with our account managers, they will update you the latest bulk GHK-Cu price in time.FAQ
What does GHK Copper Peptide do?
In humans, GHK-Cu is thought to promote wound healing, attract immune cells, have antioxidant and anti-inflammatory effects, stimulate collagen and glycosaminoglycan synthesis in skin fibroblasts, and promote blood vessel growth.
What effect does GHK-Cu have on the skin?
GHK-CU improves skin elasticity and firmness by promoting collagen formation for a youthful, radiant appearance. GHK-CU also reduces hyperpigmentation and skin imperfections for a more even and beautiful complexion.
Is GHK-Cu FDA cleared?
GHK-Cu has not been approved by the U.S. Food and Drug Administration (FDA) or any international regulatory agency for any therapeutic use in humans. But it is available as a research grade product from commercial suppliers such as peptide.ltd.
Should I use GHK-Cu Peptide daily?
You can introduce peptides into your routine at any age, from your 20s all the way through your 60s. Twice daily application of Copper Peptides leaves the complexion repaired, hydrated and more elastic.
What are the best peptides for hair loss?
RU58841 and GHK-Cu peptide stand out as the top peptides for hair growth, providing an effective solution to combat hair loss and promote regrowth. BPC 157 is a specific peptide that also plays a vital role in supporting healthy hair growth.
Who Needs GHK-Cu Peptides?
GHK-Cu peptides are known for their anti-aging benefits on the skin, but there is also evidence that they may play a role in improving hair care habits and overall health: hair growth. Additionally, it is suitable for treating patients with acute lung injury and for dealing with stress and anxiety.
What are the natural sources of GHK-Cu Peptides?
Copper is highest in protein foods such as offal, shellfish, fish, nuts and seeds, as well as whole grains and chocolate. If the diet is low in copper, copper absorption in the body increases; if the body is adequate in copper, copper absorption decreases.
Can I Overuse GHK-Cu Peptides?
While GHK-Cu peptides are milder than retinoids, overuse should be avoided as it may lead to free radical damage and collagen breakdown.
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Referenced Citations
[1]Pickart, L; Thaler, MM (1973). “Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver”. Nature New Biology. 243 (124): 85–87. PMID 4349963
[2]Pilgeram, L; Pickart, L (1968). “Control of fibrinogen biosynthesis; the role of free fatty acids”. Journal of Atherosclerosis Research. 8 (1): 155–166. doi:10.1016/s0368-1319(68)80089 -4. PMID 5642099
[3]Pickart, L (1973), A tripeptide in human plasma that increases the survival of hepatocytes and the growth of hepatoma cells, Ph.D. Thesis in Biochemistry: University of California, San Francisco
[4]Schlesinger, DH; Pickart, L; Thaler, MM (1977). “Growth-modulating serum tripeptide is glycyl-histidyl-lysine”. Cellular and Molecular Life Sciences. 33 (3): 324–325. doi:10.1007/BF02002806. PMID 858356. S2CID 29422959.
[5]Pickart, L; Freedman, JH; Loker, WJ; et al. (1980). “Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells”. Nature. 288 (5792): 715–717. Bibcode:1980Natur. 288..715P. doi:10.1038/288715a0. PMID 7453802. S2CID 4304271
[6]Maquart, FX; Pickart, L; Laurent, M; Gillery, P; Monboisse, JC; Borel, JP (1988). “Stimulation of collagen synthesis in fibroblast cultures by the tripleptide-copper complex glycyl-L-histidyl-L-lysine -Cu2+”. FEBS Letters. 238 (2): 343–6. doi:10.1016/0014-5793(88)80509-x. PMID 3169264. S2CID 19289897
[7]Wegrowski, Y.; Maquart, F.X.; Borel, J.P. (1992). “Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex Glycyl-L-histidyl-L-lysine-Cu2+”. Life Sciences. 51 (13): 1049 –1056. doi:10.1016/0024-3205(92)90504-i. PMID 1522753
[8]Maquart, FX; Bellon, G; Pasco, S; Monboisse, JC (2005). “Matrikines in the regulation of extracellular matrix degradation”. Biochimie. 87 (3–4): 353–60. doi:10.1016/j.biochi .2004.10.006. PMID 15781322
[9]Siméon, A; Wegrowski, Y; Bontemps, Y; Maquart, FX (2000). “Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+ )”. The Journal of Investigative Dermatology. 115 (6): 962–8. doi:10.1046/j.1523-1747.2000.00166.x. PMID 11121126
[10]Siméon, Alain; Emonard, Hervé; Hornebeck, William; Maquart, François-Xavier (2000). “The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures”. Li fe Sciences. 67 (18): 2257–2265. doi:10.1016/s0024-3205(00)00803-1. PMID 11045606
[11]Gul, NY; Topal, A; Cangul, IT; Yanik, K (2008). “The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits”. Veterinary Dermatology. 19 (1): 7–14 .doi:10.1111/j.1365-3164.2007.00647.x. PMID 18177285
[12Pickart L. Compositions for accelerating wound healing in mammals containing cupric salt or complexes with amino acid or peptide. US Patent 5,164,367, 1992.
[13]Kartha, R; Jayakumar, R (2007). “A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices”. Life Sciences. 80 (4): 275–84. doi:10.1016/j.lfs.2006.09.018 . PMID 17049946
[14]Gorouhi, F.; Maibach, H.I. (2009). “Role of topical peptides in preventing and treating aged skin”. International Journal of Cosmetic Science. 31(5): 327–345. doi:10.1111/j.1468-2494.2009. 00490.x. PMID 19570099. S2CID 20558453
[15]Pickart-Margolina (2018). “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data”. International Journal of Molecular Sciences. 19 (7): 7. doi:10.3390/ijms19071987. PMC 6073405. PMID 29986520.
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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